Figure 3 | Scientific Reports

Figure 3

From: Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation

Figure 3

Lys39Ala LPA1 mutant failed to mobilize intracellular calcium in response to LPA-type agonists.

(a, i–vi) dose-response curves of wildtype, Lys39Ala, R3.28A, K7.35 stimulated by various LPA-type and AGP (18:1) agonists. (vii). Confocal microscopy images in Triton-X100 permeabilized and non-permeabilized samples.

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