Figure 2 | Scientific Reports

Figure 2

From: MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy – comparison with human epileptic samples

Figure 2

Time course patterns of miRNA expression in the rat granule cell layer (GCL).

The boxplots depict the time course of expression for 6 of the miRNAs identified as significant with a false discovery rate (FDR) < 10% in the GCL by using one-way ANOVA. Each boxplot represents 4 animals. These miRNAs were chosen as representative of the different patterns that were observed: up-regulation (miR-21-5p) or down-regulation (miR-222-3p) during latency; up-regulation (miR-181c-5p) or down-regulation (miR-500-3p) in the chronic period; up-regulation (miR-146a-5p) or down-regulation (miR-551b-3p) in the entire course of the disease. The time courses of the other significantly modified miRNAs are shown in Supplementary Figs. S2, S3, S4, S5 and S6. *p < 0.05; **p < 0.01; ***p < 0.001; Tukey’s test.

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