Figure 5 | Scientific Reports

Figure 5

From: MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy – comparison with human epileptic samples

Figure 5

Plasma miRNA levels.

(A) Heat map representation of the average levels of the 27 differentially expressed miRNAs in the plasma of epileptic and control animals. Each column represents an individual animal and each row represents one miRNA, as indicated. Colors represent the expression level fold change: higher-red, lower-green. Analysis was performed on differentially represented miRNAs using the Person correlation. (B) The boxplots depict the time course for 4 of the miRNAs identified as significant by using one-way ANOVA. Each boxplot represents 5 animals. These miRNAs were chosen as representative of the different patterns that were observed: up-regulation (miR-9a-5p) or down-regulation (miR-598-5p) during latency, down-regulation in the late latency - first spontaneous seizure period (miR-381-3p) and down regulation in the chronic stage (miR-142-5p). (C) Relative levels of miR-9a-5p and miR-142-3p, as detected using qPCR. Five rats per group. *p < 0.05; **p < 0.01; ***p < 0.001; Tukey’s test.

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