Figure 2
From: The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
The effects of ganciclovir were investigated in the cuprizone model of de- and remyelination.
After 5 weeks of cuprizone feeding, complete demyelination occurred as shown by the immunohistochemical staining for the myelin protein proteolipid protein (PLP) (A). One week after cuprizone withdrawal at week 6 remyelination was visible. Total microglia numbers were analyzed by Iba1 staining, while proliferating microglia were visualized by double staining for Iba1/Ki67 (B,C). No effects of ganciclovir on de- and remyelination and microglial numbers could be observed between cuprizone groups. Each bar represents the mean ± SEM, n = 6 per time point and group.
