Table 2 Association between renal function (eGFR or CCr) and bone mineral density (low vs. high) by menopausal status.

From: Association of Renal Function and Menopausal Status with Bone Mineral Density in Middle-aged Women

Renal function

Overall (n = 1,419)

Premenopause (n = 1,101)

Postmenopause (n = 302)

P interaction

n (L/H)

AOR (95% CI)

n (L/H)

AOR (95% CI)

n (L/H)

AOR (95% CI)

eGFR (mL/min/1.73 m2)

 ≥80a

306/579

1.00

209/511

1.00

94/62

1.00

0.21

 <80a

162/372

0.69 (0.53–0.89)

75/306

0.63 (0.46–0.86)

86/60

0.85 (0.51–1.44)

CCr (mL/min)

 ≥78a

171/490

1.00

117/428

1.00

51/54

1.00

0.60

 <78a

297/461

1.48 (1.15–1.90)

167/389

1.43 (1.07–1.92)

129/68

1.53 (0.89–2.63)

  1. Abbreviations: L, low BMD; H, high BMD; AOR, adjusted odds ratio; CI, confidence interval; BMD, bone mineral density; eGFR, estimated glomerular filtration rate; CCr, creatinine clearance rate.
  2. All models were adjusted for age, menopausal status (yes/no), body weight (for eGFR model only), hypertension, low-density lipoprotein cholesterol, fasting glucose, serum alkaline phosphatase, serum uric acid, height (for CCr model only) and use of Chinese herb (yes/no).
  3. Numbers in bold indicated statistical significant findings.
  4. aThe cutoff values of eGFR (80 mL/min/1.73 m2) and CCr (78 mL/min) were determined by maximizing the Youden’s index.
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