Table 3 Adjusted mean BMD level by high and low renal function (eGFR or CCr) and menopausal status.

From: Association of Renal Function and Menopausal Status with Bone Mineral Density in Middle-aged Women

Renal function

Overall (n = 1,419)

Premenopause (n = 1,101)

Postmenopause (n = 302)

P interaction

n

Adjusted BMDa Mean ± S.E. (g/cm2)

P c

n

Adjusted BMD Mean ± S.E. (g/cm2)

P c

n

Adjusted BMD Mean ± S.E. (g/cm2)

P c

eGFR (mL/min/1.73 m2)

 ≥80b

885

1.18 ± 0.14

0.001

720

1.20 ± 0.13

<0.0001

156

1.10 ± 0.15

0.20

0.90

 <80b

534

1.21 ± 0.14

381

1.24 ± 0.12

146

1.12 ± 0.14

CCr (mL/min)

 ≥78b

661

1.22 ± 0.13

<0.0001

545

1.23 ± 0.12

<0.0001

105

1.14 ± 0.14

0.001

0.24

 <78b

758

1.17 ± 0.14

556

1.20 ± 0.13

197

1.09 ± 0.14

  1. Abbreviations: S.E., standard error; BMD, bone mineral density; eGFR, estimated glomerular filtrationrate; CCr, creatinine clearance rate.
  2. Numbers in bold indicated statistical significant findings.
  3. aAdjusted BMD was obtained from linear regression models adjusting for age, menopausal status (yes/no), body weight (for eGFR model only), hypertension, low-density lipoprotein cholesterol, fasting glucose, serum alkaline phosphatase, serum uric acid, height (for CCr model only) and use of Chinese herb (yes/no).
  4. bThe cutoff values of eGFR (80 mL/min/1.73 m2) and CCr (78 mL/min) were determined by maximizing the Youden’s index.
  5. cP-values were obtained from Mann-Whitney U test.
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