Table 4 Association between renal function (eGFR or CCr) and BMD by the use of Chinese herb.

From: Association of Renal Function and Menopausal Status with Bone Mineral Density in Middle-aged Women

Renal function

Use of Chinese herb

P interaction

No (n = 1,296)

Yes (n = 120)

n (L/H)

AOR (95% CI)

n (L/H)

AOR (95% CI)

eGFR (mL/min/1.73 m2)

 ≥80a

523/279

1.00

54/27

1.00

0.03

 <80a

353/141

0.62 (0.47–0.82)

18/21

1.77 (0.72–4.36)

CCr (mL/min)

 ≥78a

451/153

1.00

37/18

1.00

0.57

 <78a

425/267

1.48 (1.14–1.94)

35/30

1.18 (0.46–3.01)

  1. Abbreviations: L, low BMD; H, high BMD; BMD, bone mineral density; OR, odds ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; CCr, creatinine clearance rate.
  2. All models were adjusted for age, body weight (for eGFR model only), menopausal status, hypertension, low-density lipoprotein cholesterol, fasting glucose, serum alkaline phosphatase, serum uric acid, and height (for CCr model only).
  3. Numbers in bold indicated statistical significant findings.
  4. aThe cutoff values of eGFR (80 mL/min/1.73 m2) and CCr (78 mL/min) were determined by maximizing the Youden’s index.
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