Table 2 Anti-mycobacterial activity of compounds 18 against Mtb H37Ra, showing colony counts after four weeks of exposure to each compound.

From: The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

Compound

Compound concentration (μg/ml)

100

50

10

5

1

0.1

1

+++

+++

+++

+++

+++

+++

2

++

++

+++

+++

+++

+++

3

+

++

+++

+++

+++

+++

4

++

+++

+++

+++

+++

5

+++

+++

+++

+++

+++

+++

6

++

+++

+++

+++

7

+++

+++

+++

+++

+++

+++

8

+++

+++

+++

+++

+++

PAS (4 μg/ml)

++

  1. −no growth; +, 1–10 colonies; ++, 11–100 colonies; +++, colonies too numerous to count.