Table 1 List of the generated CB1 mutants.

From: Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments

Mutation List

Pocket

Residue Exchange

Position

CB1

CB2

Mutation

P1

1.45

Phe

Leu

F1.45L

7.51

Ile

Val

I7.51V

8.54

Phe

Ala

F8.54A

P2

1.55

Cys

Tyr

C1.55Y

2.41

His

Leu

H2.41L

4.46

Phe

Leu

F4.46L

P3

3.27

Phe

Leu

F3.27L

3.34

Ala

Met

A3.34M

4.54

Ile

Ala

I4.54A

P4

3.29

Leu

Ile

L3.29I

6.58

Asp

Ser

D6.58S

7.33

Thr

Lys

T7.33K

P5

4.52

Ile

Leu

I4.52L

4.56

Ile

Val

I4.56V

5.46

Val

Phe

V5.46F