Figure 1 | Scientific Reports

Figure 1

From: Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex

Figure 1

Comparison of FG Nups and DisProt proteins in terms of their charge content and distribution.

Top Row: Probability density distribution (a) and box plot (b) of mean absolute net charge, defined as absolute net charge divided by the length of the sequence. FG Nups exhibit lower absolute net charge compared to the DisProt database–please refer to “Methods” for the definition of database of FG Nups and Disprot. Interestingly, DisProt proteins show a much wider range of mean absolute net charge compared to FG Nups, implying that FG Nups share the same charge content (number density and distribution) characteristics across species. Bottom Row: Probability density distribution (c) and box plot (d) of number density of charged residues, defined as the number of charged residues divided by the length of the entire sequence. Sequences of FG Nups feature lower density of charged residues compared to DisProt. The two comparisons imply that charged residues are not only responsible for the disorderedness of FG Nups, but are also carefully distributed to give specific functionalities to FG Nups. Note that the area under each curve equals one, which explains why the values on vertical axes could exceed unity.

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