Figure 5

LMP7 in bone marrow and non-bone marrow cells contributes to the development of obesity.

(A) Representative images of immunostaining for LMP7 in epididymal and subcutaneous WAT of HFD-fed WT mice. (B) Body weight change of WT → WT, LMP7^−/− → WT, WT → LMP7^−/− mice on HFD (n = 10–11). (C) Relative weights (tissue weight/body weight) of WT → WT, LMP7^−/− → WT, WT → LMP7^−/− mice on HFD (n = 10–11). (D) Representative abdominal images of WT → WT, LMP7^−/− → WT, WT → LMP7^−/− mice on HFD by CT analysis (blue: muscle, pink: visceral fat, yellow: subcutaneous fat). (E) Quantitative analysis of muscle, visceral fat and subcutaneous fat contents (n = 10–11). Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01.