Table 2 Identified metabolite associated with NP in the CON–NP OPLS-DA model.

From: Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls

Identified metabolite

w* [CI]

p-value

q-valuea

Nonanoic acid

0.156 [0.127–0.186]

8.14 × 10−18*

0.0006#

D-Glucose

0.117 [0.091–0.143]

3.65 × 10−8*

0.0041#

D-Glucose

0.114 [0.079–0.148]

3.86 × 10−7*

0.0058#

D-Glucose

0.104 [0.079–0.128]

4.41 × 10−7*

0.0056#

Adenosine-5-monophasphate

0.098 [0.045–0.152]

6.24 × 10−5*

0.0095#

Tetradecanoic acid (Myristic acid)

0.088 [0.062–0.115]

0.0006*

0.0134#

cis-11- Eiocosenoic acid (Gondoic acid)

0.083 [0.03–0.136]

0.0001*

0.0103#

Inositol-1-phosphate

0.082 [0.025–0.138]

0.0016*

0.0148#

Succininc acid

0.077 [0.043–0.111]

0.0008*

0.0136#

Octadecadienoic acid (Linoleic acid)

0.062 [0.014–0.11]

0.0023*

0.0167#

Saccharopine

0.051 [0.008–0.094]

0.047*

0.0257

Hexadecanoic acid (Palmitic acid)

0.05 [0.004–0.096]

0.019*

0.0222#

Octadec-9-enoic acid (Oleic acid)

0.05 [0–0.099]

0.018*

0.022#

O-phosphoethanolamine

0.043 [0.006–0.079]

0.211

0.0337

L-Valine

0.042 [0.005–0.079]

0.031*

0.0245

Arachidonic acid

0.038 [0.007–0.069]

0.033*

0.0247

L-Aspartic acid

0.034 [0.001–0.066]

0.027*

0.0243

  1. Metabolites have w*cross-validated confidence intervals (95%) not including 0. * = significant change from CON p>0.05 (one-way ANOVA). # = significant change from CON (one-way ANOVA) after false discovery rate correction60. Metabolites are sorted with the most positive w* on top, i.e. the most closely associated with NP in the OPLS-DA model. Multiple entries of the same metabolite reflect different degrees of derivatisation or split peaks.
  2. aThe q-value for each individual ANOVA is the minimal level at which the p-value of that ANOVA may be considered significant60.
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