Table 5 Identified metabolite associated with CON in the CON–CWP OPLS-DA model.

From: Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls

Identified metabolite

w* [CI]

p-value

q-value

Threonic acid

−0.185 [−0.259– −0.11]

0.0009*

0.0002

Cholesterol

−0.099 [−0.194– −0.003]

0.0898

0.0058

Campesterol

−0.092 [−0.134– −0.05]

0.1165

0.0070

D(-)Quinic acid

−0.082 [−0.138– −0.026]

0.1469

0.0084

β-Sitosterol

−0.053 [−0.098– −0.008]

0.3672

0.0191

  1. Metabolites have w*cross-validated confidence intervals (95%) not including 0. * = Significant change from CWP p > 0.05 (one-way ANOVA). No metabolites are significantly (one-way ANOVA) different between after false discovery rate correction i.e. have a p-value < q-value. Metabolites are sorted with the most negative w* on top, i.e. the most closely associated with CON in the OPLS-DA model.
  2. aThe q-value for each individual ANOVA is the minimal level at which the p-value of that ANOVA may be considered significant60.
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