Figure 3
From: Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma
Direct recognition of tumor cells by HER-3-reactive CD4 T cells.
The HLA-DR-53-restricted (H16, O3 and n24) and DR-9-restricted (T11) HER-3-reactive CD4 T cells were tested for their ability to directly recognize HLA-DR-matched tumor cells. HSC3 cells (DR15/15) or HSC4 cells (DR1/4, DR53) were used as an HLA-DR-unmatched negative control for DR9- or DR53-restricted HER-3-reactive CD4 T cells, respectively. L243 cells were used to verify the HLA-DR restriction of these responses. Columns: means of triplicate measurements, bars: SEM. The results shown are representative of 3 separate experiments.
