Figure 4 | Scientific Reports

Figure 4

From: Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia

Figure 4

Localization of the mutations observed on the HSPA9 protein structure.

(A) Mapping of the R126W and Y128C mutation of the crystal structure of the NBD (light blue). Both mutations lie on the surface of the protein, opposite to the nucleotide binding site. R126W is shown in red, Y128C in yellow. (B) Localization of the mutations in relation to the NBD/SBD interface (NBD and SBD shown in light green and purple respectively) in a model of the full length protein. Only a portion of the SBD is shown for clarity. Both mutations are located on a single loop near the interface, as shown in detail in the inset.

Back to article page