Table 2 Association statistics for the known CRC SNPs tested in EC and vice versa.

From: Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Cancer GWAS	SNP	Chr	Position (build 37)	Nearby gene(s)	Minor Allele	MAF	P-value in other phenotype	OR (minor allele)	L95 CI	U95 CI	Same effect direction in CRC and EC?	iCOGS EC samples included?	Reference
CRC	rs1801133	1	11,856,378	MTHFR	A	0.34	0.686	0.99	0.92	1.06	Yes	No	Hubner et al. Int Journal Cancer2006
CRC	rs10911251	1	183,081,194	LAMC1	C	0.43	0.236	1.04	0.97	1.12	No	No	Peters et al. Gastroenterology 2013, Whiffin et al. Hum Mol Genet 2014
CRC	rs6691170	1	222,045,446	DUSP10	T	0.37	0.023	1.09	1.01	1.17	Yes	No	Houlston et al. Nat Gen 2010
CRC	rs10936599	3	169,492,101	TERC	T	0.24	0.033	0.92	0.84	0.99	Yes	No	Houlston et al. Nat Gen 2010
CRC	rs2736100	5	1,286,516	TERT	A	0.5	0.000167	0.93	0.89	0.96	No	Yes	Kinnersley Br J Cancer 2012, Rafnar et al. Nat Gen 2009 Peters et al. Human Genetics 2012
CRC	rs647161	5	134,499,092	PITX1	C	0.33	0.559	1.02	0.95	1.1	No	No	Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014
CRC	rs1321311	6	36,622,900	CDKN1A	A	0.24	0.925	1.00	0.92	1.08	No	No	Dunlop et al. Nat Gen 2012
CRC	rs16892766	8	117,630,683	EIF3H	C	0.09	0.134	0.95	0.88	1.02	No	Yes	Tomlinson et al. Nat Gen 2008
CRC	rs6983267	8	128,413,305	MYC	T	0.46	0.143	1.03	0.99	1.07	No	Yes	Tomlinson et al. Nat Gen 2007
CRC	rs10795668	10	8,701,219	GATA3	A	0.32	0.715	0.99	0.92	1.06	Yes	No	Tomlinson et al. Nat Gen 2008
CRC	rs1035209	10	101,345,366	NKX2-3, SLC25A28	T	0.2	0.243	1.05	0.97	1.15	Yes	No	Whiffin et al. Hum Mol Genet 2014
CRC	rs3824999	11	74,345,550	POLD3	T	0.49	0.647	0.98	0.92	1.05	Yes	No	Dunlop et al. Nat Gen 2012
CRC	rs3802842	11	111,171,709	COLCA1, COLCA2, POU2AF1	C	0.31	0.513	0.99	0.94	1.03	No	Yes	Tenesa et al. Nat Gen 2008
CRC	rs10774214	12	4,368,352	CCND2	T	0.38	0.171	1.05	0.98	1.13	Yes	Yes	Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014
CRC	rs3217810	12	4,388,271	CCND2	T	0.14	0.762	1.02	0.92	1.13	Yes	No	Peters et al. Gastroenterology 2013, Whiffin et al. Hum Mol Genet 2014
CRC	rs11169552	12	51,155,663	DIP2B, ATF1	T	0.26	0.963	1.00	0.93	1.08	No	No	Houlston et al. Nat Gen 2010
CRC	rs4444235	14	54,410,919	BMP4	C	0.48	0.1	1.03	0.99	1.07	Yes	Yes	Houlston et al. Nat Gen 2008
CRC	rs1957636	14	54,560,018	BMP4	T	0.41	0.961	1.00	0.96	1.04	No	Yes	Tomlinson et al. PLoS Genetics 2011
CRC	rs16969681	15	32,993,111	GREM1	T	0.09	0.379	0.97	0.90	1.04	No	Yes	Tomlinson et al. PLoS Genetics 2011
CRC	rs11632715	15	33,004,247	GREM1	A	0.48	0.332	1.04	0.97	1.11	Yes	No	Tomlinson et al. PLoS Genetics 2011
CRC	rs9929218	16	68,820,946	CDH1, CDH3	A	0.29	0.679	0.98	0.91	1.06	Yes	No	Houlston et al. Nat Gen 2008
CRC	rs4939827	18	46,453,463	SMAD7	C	0.46	0.229	0.98	0.94	1.02	Yes	Yes	Broderick et al. Nat Gen 2007
CRC	rs10411210	19	33,532,300	RHPN2	T	0.09	0.202	1.04	0.98	1.12	No	Yes	Houlston et al. Nat Gen 2008
CRC	rs961253	20	6,404,281	BMP2	A	0.37	0.975	1.00	0.96	1.04	No	Yes	Houlston et al. Nat Gen 2008
CRC	rs4813802	20	6,699,595	BMP2	G	0.37	0.268	1.04	0.97	1.12	Yes	No	Tomlinson et al. PLoS Genetics 2011
CRC	rs2423279	20	7,812,350	HAO1	C	0.24	0.897	1.01	0.93	1.09	Yes	No	Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014
CRC	rs4925386	20	60,921,044	LAMA5	T	0.3	0.064	1.07	1.00	1.16	No	No	Houlston et al. Nat Gen 2010, Peters et al. Human Genetics 2012
EC	rs749292*	15	51,558,731	CYP19A1	A	0.46	0.066	0.95	0.91	1.00	No	Yes	Spurdle et al. Nat Gen 2011
EC	rs4430796*	17	36,098,040	HNF1B	G	0.47	0.601	0.99	0.94	1.04	Yes	Yes	Setiawan et al. Cancer Epidemiol Biomarkers Prev 2009

Chr = chromosome, OR = odds ratio, MAF = minor allele frequency, OR = odds ratio, L95 CI = lower 95% confidence interval odds ratio, U95 CI = upper 95% confidence interval odds ratio. The original studies providing the data are listed in Supplementary Information.

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Table 2 Association statistics for the known CRC SNPs tested in EC and vice versa.

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