Figure 1 | Scientific Reports

Figure 1

From: Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

Figure 1

Gene expression pattern from the meta-analysis.

The upper panel shows the overlap between DE genes identified in the meta-analysis (Meta-DE) and in each individual data analysis (individual-DE). Gain genes are those identified only in the meta-analysis. Loss genes are those identified in individual studies, but not in the meta-analysis. In the lower panel, a heatmap built using the top 30 differentially-expressed genes (15 up – and 15 down-regulated) comparing the gene expression pattern of studies that enrolled patients with sickle cell disease (GSE35007 and GSE53441) is shown. Class 1 and 2 refer to control and patient samples respectively, from each individual dataset.

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