Figure 2 | Scientific Reports

Figure 2

From: Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

Figure 2

Enriched gene ontology pathways identified in the meta-analysis.

The top enriched biological processes predicted from the list of up-regulated genes generated in the meta-analysis of samples from patients with sickle cell disease were grouped with the software ClueGO as a functional cluster (using a kappa score = 0.3). Each node represents a biological process. Their associated genes are represented as dots. Node and dot colors represent the functional group to which they belong. Mixed coloring nodes and dots belong to multiple groups. One ungrouped term is shown in grey. Edges represent term-term interaction or term-genes interaction. The title of the most significant term per group is shown in the network as a group title (colored text). The size of nodes reflects the enrichment significance of the terms.

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