Table 1 Characteristics of individual studies included in the meta-analysis.

From: Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

 

Sample characteristics

Platform

GEO accession number

Size (Pt:Ctl)

Source

Experimental context

1

GSE53441

24:10

PBMC

Adults, steady-state

Affymetrix Human U133 2.0 Plus

2

GSE35007*

62:29

Whole blood**

Children, acute crisis and steady-state

Illumina HumanHT-12 v4

4

GSE25014

12:12

PAEC/PMVEC

Heme-stimulated endothelial cells

Affymetrix Human U133 2.0 Plus

5

GSE1849

12:20

PAEC

Plasma-stimulated endothelial cells

Affymetrix Human Genome U133

  1. GEO: Gene Expression Omnibus, Pt:Ctl: patients:controls; PBMC: peripheral blood mononuclear cells; PAEC: Human pulmonary artery endothelial cells, PMVEC: human pulmonary microvascular endothelial cells. *62 samples were selected samples from GSE35007, including 18 patients in acute crisis and 44 in steady-state (based on the highest severity-score informed in the database); **submitted to a globin mRNA reduction step.
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