Table 2 Significant biological terms identified in each individual study.
Steady state adults (GSE53441) – PBMC | ||
|---|---|---|
Biological term | GSA library | P value |
B cell receptor signaling pathway | KEGG | 0.0003 |
Type II interferon signaling | Wikipathways | 9.2 e-7 |
Hemoglobins chaperone | Biocarta | 6.0 e-6 |
Defense response to virus | GO biological process | 3.9e-19 |
SYK (spleen tyrosine kinase) | KEA | 8 e-5 |
ROCK2 (Rho-associated protein kinase 2) | Kinases perturbations | 0.002 |
Top severity score - children (GSE35007) – whole blood | ||
MAPK signaling pathway | KEGG | 0.02357 |
Adherens junction | KEGG | 0.04524 |
Glutathione metabolism | Wikipathways | 0.00091 |
Oxidative Stress | Wikipathways | 0.00442 |
Heme biosynthesis | Wikipathways | 0.00925 |
IL-6 signaling pathway | Wikipathways | 0.0288 |
Autophagy | GO biological process | 1.3 e-6 |
Regulation of cellular response to stress | GO biological process | 0.00008 |
Acute crisis children (GSE35007) – whole blood | ||
Porphyrin and chlorophyll metabolism | KEGG | 0.014 |
Complement and coagulation cascades | KEGG | 0.016 |
Oxidative Stress | Wikipathways | 5.6 e-4 |
Heme biosynthesis | Wikipathways | 0.005 |
Response to virus | GO biological process | 2.5 e-8 |
Autophagy | GO biological process | 8.0 e-9 |
Response to type I interferon | GO biological process | 1.0 e-8 |
