Table 3 Top 20 DE genes identified in the meta-analysis of studies with clinical samples.

From: Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

 

Fold-change in individual studies (LogFC)

Meta-analysis results

Genes

GSE53441

GSE35007

CombRP

AveLogFC

P

Up-regulated genes

HBD

3.80

4.12

6.37

3.96

<0.0001

GYPB

1.60

3.50

20.40

2.55

<0.0001

CA1

1.88

3.32

24.23

2.60

<0.0001

RUNDC3A

0.90

3.12

35.67

2.01

<0.0001

RAP1GAP

0.24

3.38

36.50

1.81

<0.0001

IFI27

2.70

3.07

37.90

2.88

<0.0001

OSBP2

0.73

3.05

40.60

1.88

<0.0001

TMCC2

1.16

2.99

40.62

2.07

<0.0001

XK

1.08

2.94

41.43

2.01

<0.0001

SLC4A1

2.44

2.82

42.16

2.63

<0.0001

Down-regulated genes

C12orf57

−0.30

−1.24

156.78

−0.77

<0.0001

CD3G

−0.31

−1.23

176.91

−0.77

<0.0001

CCR7

−0.23

−1.17

206.27

−0.70

<0.0001

IL7R

−0.22

−1.15

231.82

−0.68

<0.0001

RGS19

−0.09

−1.09

267.28

−0.59

<0.0001

C21orf7

−0.11

−1.05

270.6

−0.58

<0.0001

SNRPD3

−0.09

−1.11

293.33

−0.60

<0.0001

LRPAP1

−0.05

−1.04

306.19

−0.54

<0.0001

PARK7

−0.07

−1.05

309.77

−0.56

<0.0001

PHB2

−0.20

−0.99

333.57

−0.59

<0.0001

  1. Genes were ranked based according to the combined-rank product obtained in each meta-analysis. LogFC: base 2 log of Fold-change; CbnRP: combined Rank Product (the smaller the combRP, the higher is the likelihood of differential expression; AveLogFC: average LogFC.
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