Table 4 Top biological pathways and terms identified by GSA in the meta-analysis of studies with clinical samples.
Biological pathway | Overlap | GSA library | p-value |
|---|---|---|---|
Porphyrin and chlorophyll metabolism | 05/41 | KEGG | 9.0 e-4 |
Interferon alpha/beta signaling | 12/67 | Reactome | 1.7 e-8 |
Metabolism of porphyrins | 05/17 | Reactome | 0.007 |
Antigen processing: ubiquitination & proteasome degradation | 10/211 | Reactome | 0.007 |
Antiviral mechanism by IFN-stimulated genes | 05/71 | Reactome | 0.01 |
Apoptosis | 07/146 | Reactome | 0.02 |
Class I MHC mediated antigen processing & presentation | 10/255 | Reactome | 0.025 |
Degradation of the extracellular matrix | 05/89 | Reactome | 0.03 |
Cell surface interactions at the vascular wall | 05/99 | Reactome | 0.043 |
Signaling by TGF-beta receptor complex | 04/70 | Reactome | 0.048 |
Heme biosynthesis | 04/09 | Wikipathway | 4.7 e-5 |
Senescence and autophagy | 6/108 | Wikipathway | 0.012 |
Gene ontology term | Overlap | GSA library | p-value |
Tetrapyrrole metabolic process | 11/59 | GO | 3.2 e-8 |
Cellular response to type I interferon | 11/65 | GO | 7.9 e-8 |
Response to other organism | 26/462 | GO | 4.5 e-7 |
Autophagy | 12/102 | GO | 7.2 e-7 |
Cytokine-mediated signaling pathway | 15/342 | GO | 1.6 e-3 |
PPI hub proteins | Overlap | GSA library | p-value |
RPS27A | 11/173 | EnrichR | 3.0 e-6 |
HSPA1A | 9/145 | EnrichR | 3.0 e-5 |
DYNLL1 | 9/183 | EnrichR | 1.9 e-4 |
TNFRSF1A | 8/173 | EnrichR | 6.0 e-4 |
SMAD4 | 9/221 | EnrichR | 7 e-4 |
UBC | 16/540 | EnrichR | 2.5 e-4 |
Kinase enrichment analysis | Overlap | GSA library | p-value |
BMPR2 | 194/10324 | EnrichR | 0 |
IRAK4 | 70/2805 | EnrichR | 4.7 e-9 |
