Table 5 Top 10 DE genes identified in the meta-analysis between heme-stimulated endothelial cells and clinical samples.

From: Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

Heme-stimulated endothelial cells x plasma(ACS)-stimulated EC

Up-regulated

Down-regulated

Gene name

AveLogFC

p-value

Gene name

AveLogFC

p-value

LYPD1

4.10

<0.0001

FGF13

−4.12

<0.0001

BST2

4.20

<0.0001

PDPN

−4.22

<0.0001

DARC

3.82

<0.0001

PLA1A

−3.67

<0.0001

C7

3.77

<0.0001

PGM5

−3.90

<0.0001

CCL23

3.72

<0.0001

MRC1

−3.80

<0.0001

Heme-stimulated endothelial cells x SCD adults (PBMC/steady state)

IFI27

4.65

<0.0001

CA2

−4.40

<0.0001

IFI44L

3.90

<0.0001

KBTBD11

−3.00

<0.0001

SELENBP1

3.00

<0.0001

KRT23

−2.16

<0.0001

IFIT1

2.01

<0.0001

HSD17B2

−4.36

<0.0001

BST2

4.26

<0.0001

GPAT2

−2.36

<0.0001

Heme-stimulated endothelial cells x SCD children (whole blood/acute crisis)

IFI27

4.85

<0.0001

TCL1A

−0.98

<0.0001

CA1

1.60

<0.0001

CLC

−0.80

<0.0001

TMCC2

1.42

<0.0001

C12orf57

−1.14

<0.0001

SELENBP1

3.34

<0.0001

CD3G

−0.84

<0.0001

RUNDC3A

1.44

<0.0001

ITM2C

−2.75

<0.0001

  1. In the first panel, we present the results of the meta-analysis between the study comparing heme-stimulated endothelial cells with plasma (from patients with ACS)-stimulated endothelial cells. In the next two panels, we present the results of the meta-analysis between heme-stimulated endothelial cells versus clinical samples. Genes were ranked based according to the combined-rank product obtained in each meta-analysis. ACS: acute chest syndrome; AveLogFC: average (from both studies) of the base 2 log of Fold-change; PBMC: peripheral blood mononuclear cells.
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