Table 4 Genotype and allele frequencies distribution of IL-10 and IL-18 polymorphisms between PD patients with or without cognitive impairment.
SNP | Genotype/allele | PD-NC (n = 92) | PD-MCI (n = 76) | PD-D (n = 100) | PD-D plus PD-MCI (n = 176) | PD-D plus PD-MCI vs PD-NC | PD-D vs PD-MCI | ||
|---|---|---|---|---|---|---|---|---|---|
p a | ORa(95%CIa) | p Pa | ORa(95%CIa) | ||||||
IL10 (−592 A/C) | C | 49 (26.6%) | 43(28.3%) | 55(27.5%) | 98(27.8%) | 0.723 | 0.926 (0.606–1.415) | 0.789 | 1.072 (0.647–1.775) |
rs1800871 | T | 135 (73.4%) | 109(71.7%) | 145(72.5%) | 254(72.2%) | ||||
CC | 10 (10.4%) | 4(5.2%) | 12(12.0%) | 16(9.1%) | 0.736 | 0.933 (0.622–1.398) | 0.796 | 1.066 (0.656–1.733) | |
CT | 29 (31.4%) | 35(46.1%) | 31 (31.0%) | 66(37.5%) | |||||
TT | 53 (58.2%) | 37(48.7%) | 57 (57.0%) | 94(53.4%) | |||||
IL10 (−819 T/C) | C | 49 (28.0%) | 43(28.3%) | 56 (28.0%) | 99 (28.1%) | 0.896 | 0.973 (0.644–1.469) | 0.698 | 1.104 (0.669–1.821) |
rs1800872 | A | 135 (72.0%) | 109(71.7%) | 144 (72.0%) | 253 (71.9%) | ||||
CC | 10(10.9%) | 5(6.6%) | 13 (13.0%) | 18 (10.2%) | 0.906 | 0.976 (0.662–1.438) | 0.714 | 1.093 (0.681–1.754) | |
CA | 29 (31.5%) | 33(43.4%) | 30 (30.0%) | 63 (35.8%) | |||||
AA | 53 (57.6%) | 38(50.0%) | 57 (57.0%) | 95 (54.0%) | |||||
IL18 (−137 G/C) | C | 27 (14.7%) | 12 (7.9%) | 30(15.0%) | 42 (11.9%) | 0.572 | 1.177 (0.669–2.073) | 0.053 | 0.474 (0.222–1.010) |
rs187238 | G | 157 (85.3%) | 140 92.1%) | 170 (85.0%) | 310 (88.1%) | ||||
CC | 2 (2.2%) | 0(0.0%) | 4 (4.0%) | 4 (2.3%) | 0.578 | 1.171 (0.672–2.041) | 0.069 | 0.511 (0.248–1.055) | |
CG | 23 (25.0%) | 12 (15.8%) | 22 (22.0%) | 34 (19.3%) | |||||
GG | 67 (72.8%) | 64(84.2%) | 74 (74.0%) | 138 (78.4%) | |||||
