Figure 7 | Scientific Reports

Figure 7

From: Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer

Figure 7

Cancer biological response to energy depletion.

(A) In CT26, cell viability progressively decreased with increasing MTF doses. This response was further amplified by STS (dashed columns). (B) This effect was more evident in 4T1 cells in which the cytotoxicity of MTF + STS was already massive at 5 mM MTF. (C,D) Proliferation rate was reduced under each condition with a largely additive effect of MTF and STS, both in CT26 (C) and 4T1 (D) cells. At Western blot evaluation in CT26 cells, STS, MTF and mostly merged treatment caused a decrease in PI3K (E) and pAKT expression (F) despite a stable expression of PTEN in all conditions (G). Data are presented as mean ± SD; (*p < 0.05; **p < 0.01 statistical differences vs controls).

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