Figure 5 | Scientific Reports

Figure 5

From: High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

Figure 5

IL15-driven maturation of NK cells occurs independently of IL15 trans-presentation.

The maturation state of NKp46+ NK cells was analyzed flow cytometry. (A) Representative FACS plots of CD27 and CD11b staining on NKp46+ cells in the spleen and bone marrow. (B) Summarized frequencies of NK cell maturation stages in spleen and bone marrow (n = 4–7). Percentages of (C) KLRG1+ and (D) Ly49G2+ in NKp46+ cells in the spleen. Statistics: ***p<=0.001; *p<=0.05; ns = non significant.

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