Figure 5 | Scientific Reports

Figure 5

From: The Quorum Sensing Inhibitor Hamamelitannin Increases Antibiotic Susceptibility of Staphylococcus aureus Biofilms by Affecting Peptidoglycan Biosynthesis and eDNA Release

Figure 5

Effect of treatment on lysostaphin susceptibility and thickness of the cell wall.

(a) OD590 nm (average ± s.d.) after 10 min lysostaphin treatment of S. aureus Mu50 biofilm cells receiving no pre-treatment (CTRL) or a pre-treatment with HAM, VAN or a combination of HAM and VAN (COMB). The OD590nm after 10 min was compared to the OD590 before the addition of lysostaphin (set at 100%).*the percentage OD590 nm is significantly different from that of the cells receiving pre-treatment with VAN (n ≥ 6; one-way; p < 0.05). (b) Changes in cell wall thickness of S. aureus Mu50 biofilm cells receiving no treatment (CTRL) or a treatment with HAM, VAN or a combination of HAM and VAN (COMB). Significant (n ≥ 100 cells; one way; p < 0.001) differences in cell wall thickness were observed between the untreated and VAN treated biofilm cells and between biofilm cells receiving a treatment with VAN or a combination of VAN and HAM.

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