Figure 7
Effect of treatment on expression of virulence genes and hemolytic activity.
(a) Fold changes in expression of selection of virulence genes in S. aureus Mu50 biofilms treated with VAN (black bars) or a combination of VAN and HAM (grey bars) compared to expression in untreated biofilm cells. *significant (p < 0.01) differences are observed in gene expression between biofilm cells treated with VAN or a combination of VAN and HAM. (b) OD420 nm (average ± s.e.m.) (as indication of hemolytic activity) of rabbit blood incubated with the supernatant of S. aureus Mu50 untreated biofilm cells (CTRL) or biofilm cells treated with HAM or VAN alone or a combination of VAN and HAM (COMB). *significant (p < 0.01) differences in OD420 nm between biofilm cells treated with VAN or a combination of VAN and HAM and between untreated biofilms and HAM treated biofilms.
