Figure 3
From: Negative regulation of initial steps in skeletal myogenesis by mTOR and other kinases
Hit kinases intersect with individual proteins in biological pathways that are relevant to skeletal muscle differentiation.
Genetic interaction network for hits without PD (A) and with PD (B) linking MyoD- and Mef2-family MRFs (pink) to selected kinases (yellow). Note that one hit kinase, CSNK2A2 (B, arrow), shows a direct connection to MYF5, while others represent all hit kinases interacting semi-directly through one interaction node (light blue). Asterisks (A) denote the hit kinase, MRF and interacting node with the greatest number of interactions. Several of these semi-direct regulators were identified in both the sensitized screen and non-sensitized screens (arrowheads).
