Figure 6
From: WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts
WISP1 increases proliferation of phLFs in part via IL-6.
The phLFs were either (A) transfected with siCtrl or siWISP1 or (B) pre-incubated with a neutralizing αWISP1 antibody and treated with or without IL-6 (10 ng/ml). Metabolic activity of the phLFs was measured by WST-1 conversion and statistically significant increases were observed following IL-6 treatment demonstrating that IL-6 induction is, in part, responsible for mediating the pro-proliferative effects of WISP1 (n = 7; *p < 0.05; Student’s T-test).
