Table 3 Effects of thalidomide on cultured embryos 24 h after incubation.
From: Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model
CYP3A-HAC | Thalidomide | n | Crown-rump length (mm) | Total number of somites (No.) | Total protein contents (μg/embryo) | Number of embryos with abnormalities |
|---|---|---|---|---|---|---|
− | − | 40 | 8.8 ± 0.5 | 69.3 ± 3.2 | 2778 ± 557 | 0 (0%) |
− | + | 56 | 8.8 ± 0.6 | 67.5 ± 3.6 | 2821 ± 534 | 0 (0%) |
+ | − | 12 | 8.8 ± 0.5 | 71.2 ± 1.5 | 2838 ± 658 | 0 (0%) |
+ | + | 21 | 8.9 ± 0.5 | 68.2 ± 2.8 | 2708 ± 671 | 9 (42.9%)*** |
