Table 2 Cox regression analysis for the prognostic value of DDX3, pDvl2, nuclear β-catenin and their combinations on OS and RFS in colorectal cancer patients.

From: DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

Variables

OS

RFS

Case No.

Adjusted HR

95% CI

P

Case No.

Adjusted HR

95% CI

P

DDX3

 Low

44

1

  

44

1

  

 High

31

2.57

1.19–5.56

0.016

31

2.26

1.14–4.45

0.019

pDvl2

 Low

39

1

  

39

1

  

 High

36

3.07

1.34–7.05

0.008

36

2.79

1.35–5.75

0.005

Nuclear β-catenin*

 Low

39

1

  

39

1

  

 High

36

3.97

1.71–9.26

0.001

36

2.96

1.43–6.12

0.004

DDX3/pDvl2

 Others

53

1

  

53

1

  

 High/high

22

4.55

2.01–10.29

<0.001

22

2.71

1.37–5.36

0.004

DDX3/Nuclear β-catenin

 Others

54

1

  

54

1

  

 High/High

21

5.61

2.49–12.65

<0.001

21

2.67

1.35–5.27

0.005

DDX3/pDvl2/Nuclear β-catenin

 Others

55

1

  

55

1

  

 +/+/+

20

4.78

2.13–10.72

<0.001

20

2.41

1.22–4.78

0.012

  1. OS: overall survival; RFS: relapse free survival; HR: haozard ratio.
  2. *High-nuclear β-catenin tumors were defined as high-nuclear β-catenin/high-cytoplasmic β-catenin (N+/C+) and high-nuclear β-catenin/low-cytoplasmic β-catenin N+/C−; otherwise, low-nuclear β-catenin tumors were defined as N−/C− and N−/C+.
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