Figure 3: Changes in CAR, PXR, and AHR mRNA levels during hepatic differentiation of hESCs and hiPSCs.

Expression levels of CAR (a), PXR (b), and AHR (c) mRNA in differentiated hESCs and hiPSCs at day 0, 5, 10, and 18 and in human adult and fetal liver were measured by qRT-PCR. Results represent mean ± SD (n = 3). **p < 0.01, ***p < 0.001, significant values in comparison with adult liver. AL, adult liver; FL, fetal liver.