Figure 5: Ligand-induced transcriptional activation of CAR, PXR, and AHR in hPSC-HLCs. | Scientific Reports

Figure 5: Ligand-induced transcriptional activation of CAR, PXR, and AHR in hPSC-HLCs.

From: Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

Figure 5

Inductions of CAR-, PXR-, and AHR-target genes in hESC-HLCs (a) and hiPSC-HLCs (b) treated with receptor-specific ligands for 6 h and 24 h were determined by qRT-PCR. CITCO (100 nM), SR12813 (200 nM), and ITE (500 nM) were used as agonists of CAR, PXR, and AHR, respectively. Results represent mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, significant values in comparison with 0.1% DMSO control (Con).

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