Figure 7: Ligand-dependent CYP1A1 and CYP1B1 induction in hPSC-HLCs. | Scientific Reports

Figure 7: Ligand-dependent CYP1A1 and CYP1B1 induction in hPSC-HLCs.

From: Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

Figure 7

Cells were treated with 1 μM BaP, 10 nM TCDD, 1 μM 3-MC, or DMSO (0.1%) for indicated amounts of time. Ligand-induced CYP1A1 (a, c) and CYP1B1 (b, d) expression in hESC-HLCs (a, b) and hiPSC-HLCs (c, d) were determined by qRT-PCR analysis. Results are presented as the mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, significant values in comparison with DMSO.

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