Figure 8: TMF antagonized AHR-mediated target gene expression. | Scientific Reports

Figure 8: TMF antagonized AHR-mediated target gene expression.

From: Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

Figure 8

PHHs and hESC- and hiPSC-HLCs were treated with vehicle (DMSO), 1 μM BaP, 10 nM TCDD, and 1 μM 3-MC with or without 10 μM TMF for 6 h. Expression levels of AHR-responsive CYP1A1 and CYP1B1 in PHHs (a), hESC-HLCs (b), and hiPSC-HLCs (c) were determined by qRT-PCR analysis. Results are presented as the mean ± S.D (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, significant values in comparison with cells treated with indicated compounds without TMF.

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