Table 1 Metabolomic profiling of kidneys in Eker rats (Tsc2+/−) from ST (N = 6), KD4 (N = 4), KD6 (N = 6) and KD8 (N = 5) groups.

From: Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis

 

ST

KD4

KD6

KD8

D-Glucuronic acid

150 ± 34

38 ± 29

3.8 ± 1.5**

28 ± 26*

Glyceric acid

0.34 ± 0.09

2.74 ± 0.65**

4.12 ± 1.28**

0.11 ± 0.02

Guanosine

0.7 ± 0.19

0.17±0.06*

0.17 ± 0.07**

0.8 ± 0.23

Oleic acid

0.16 ± 0.01

0.57 ± 0.12**

0.41 ± 0.04**

0.28 ± 0.03*

Scyllo-Inositol

3.6 ± 0.53

2.1 ± 0.45

1.1 ± 0.26*

0.46 ± 0.13**

Succinic acid

1.37 ± 0.46

0.24 ± 0.04**

0.25 ± 0.06**

0.96 ± 0.24

  1. Values represent mean fold change ± SEM. *P < 0.05, **p < 0.01 respectively to the ST group (ANOVA with a Tukey’s post hoc test). KD4, KD6, KD8 – groups treated with HFKD for four, six or eight mo., respectively; ST – control animals fed with a standard diet.
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