Table 3 Results of the reliability and subgroup analysis of findings from the 17 DTI studies (18 datasets) with TBSS included in the meta-analysis.

From: Disorganization of white matter architecture in major depressive disorder: a meta-analysis of diffusion tensor imaging with tract-based spatial statistics

Analysis

Region of FA reduction: Genu of CC

Region of FA reduction: ALIC

Jackknife sensitivity analysis (discarded study)

Excluding Zuo et al. 2012 [20]

Yes

Yes

Excluding Lai et al. 2014 [21]

Yes

Yes

Excluding Zhu et al. 2011 [22]

Yes

Yes

Excluding Versace et al. 2010 [23]

Yes

Yes

Excluding Choi et al. 2014 [24]

Yes

Yes

Excluding Murphy et al. 2012 [31]

Yes

Yes

Excluding Guo et al. 2012 [32]

Yes

Yes

Excluding Han et al. 2014 [33]

Yes

Yes

Excluding Hayashi et al. 2014 [34]

Yes

Yes

Excluding Kieseppa et al. 2010 [35]

Yes

Yes

Excluding Lyden et al. 2014 [36]

Yes

Yes

Excluding Olvet et al. nMDD 2014 [37]

Yes

No

Excluding Olvet et al. sMDD 2014 [37]

Yes

Yes

Excluding Seok et al. 2013 [38]

Yes

Yes

Excluding Guo et al. 2012 [39]

Yes

No

Excluding Korgaonkar et al. 2011 [40]

Yes

Yes

Excluding Wang et al. 2014 [41]

Yes

Yes

Excluding Xiao et al. 2015 [42]

Yes

No

Descriptive analysis of quartiles

First quartile (25%)

Yes

No

Second quartile (median)

Yes

No

Third quartile (75%)

No

No

Subgroup analysis

Studies with first-episode, treatment-naive MDD (n = 7)

No

Yes

Studies with Medication free MDD (n = 14)

Yes

Yes

  1. “Yes” indicates that the brain region with FA reduction remained significant in the jack-knife analysis, descriptive analysis of quartiles and subgroup analysis; “No” indicates that the brain region with FA reduction was no longer significant in those analyses.
  2. Abbreviations: DTI, diffusion tensor imaging; TBSS, tract-based spatial statistics; FA, fractional anisotropy; CC, corpus callosum; ALIC, anterior limb of internal capsule; MDD, major depressive disorder; nMDD, depressed patients without a history of suicide attempts; sMDD, depressed patients with a history of suicide attempts.