Figure 2
From: Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
In vitro mRNA delivery of TNT LLNs in Hep 3B cells.
(A) TNT-b10 LLNs showed higher transfection efficiency than TNT-a10, TNT-b8, TNT-b12 and TNT-b14 LLNs. **p < 0.01 as determined by an unpaired student’s t-test. These results indicate that not only the length of carbon chains but also the position of functional groups of lipid-like compounds have dramatic effects on delivery efficiency. (B) The effect of phospholipids on LLNs-mediated transfection. DOPE-formulated LLNs were more efficient for mRNA delivery compared to DSPC and POPE-formulated LLNs. **p < 0.01 as determined by an unpaired student’s t-test.
