Figure 2
Comparison of peptide p5 and p5+14 amyloid reactivity in vitro and in vivo.
(A) Binding of 125I-p5 (grey circles) and 125I-p5+14 (black circles) to rVλ6Wil fibrils, by peptide binding assay, in solutions of increasing ionic strength (mean ± SD; SD was <10% for all points and error bars are not visible). The data were fit with a sigmoid equation using Prism. (B) Dual-energy tissue biodistribution of 125I-p5+14 and 99mTc-p5 in AA mice. Bars represent the mean %ID/g (n = 3) with SD. Individual data points for each mouse are shown. Data were analysed by using an independent t-test with a Bonferroni corrected α value of 0.01, where *p < 0.01.
