Table 1 Risk of cancer of unknown primary for offspring with first degree relatives diagnosed with cancer.

From: Location of metastases in cancer of unknown primary are not random and signal familial clustering

Cancer in relatives

Parental only

Sibling only

Parent and sibling

First degree relatives

O

SIR

95%CI

O

SIR

95%CI

O

SIR

95%CI

O

SIR

95%CI

Upper aerodigestive tract

146

1.33

1.12

1.56

58

1.12

0.85

1.44

2

1.94

0.18

7.13

206

1.26

1.10

1.45

Esophagus

52

1.28

0.95

1.68

23

1.28

0.81

1.92

1

7.22

0.00

41.39

76

1.29

1.02

1.62

Stomach

239

0.96

0.84

1.09

44

1.13

0.82

1.51

3

1.31

0.25

3.87

286

0.98

0.87

1.10

Colorectum

564

0.96

0.88

1.04

237

1.12

0.98

1.26

24

1.83

1.17

2.63

825

1.01

0.95

1.08

Colon

347

0.92

0.83

1.02

134

1.03

0.87

1.23

18

1.78

1.05

2.81

499

0.97

0.88

1.05

Rectum

217

1.02

0.89

1.16

103

1.25

1.02

1.51

6

1.98

0.71

4.35

326

1.09

0.98

1.22

Liver

177

1.14

0.98

1.33

54

1.40

1.05

1.83

4

3.94

1.03

10.19

235

1.21

1.06

1.38

Pancreas

152

1.01

0.85

1.18

54

1.19

0.90

1.56

4

2.87

0.75

7.42

210

1.06

0.92

1.22

Lung

404

1.19

1.07

1.31

284

1.71

1.52

1.92

25

2.43

1.57

3.59

713

1.38

1.28

1.48

Breast

484

1.00

0.91

1.10

435

1.17

1.06

1.29

35

1.10

0.77

1.53

954

1.08

1.01

1.15

Cervix

103

1.09

0.89

1.33

44

1.09

0.79

1.46

0

   

147

1.09

0.92

1.28

Endometrium

125

0.96

0.80

1.15

68

0.99

0.77

1.26

2

1.10

0.10

4.04

195

0.97

0.84

1.12

Ovary

121

1.12

0.93

1.34

62

1.07

0.82

1.37

5

3.41

1.08

8.03

188

1.12

0.97

1.30

Prostate

706

1.05

0.98

1.13

361

1.07

0.96

1.19

48

0.91

0.67

1.21

1115

1.05

0.99

1.12

Kidney

171

1.11

0.95

1.29

69

1.22

0.95

1.54

3

1.96

0.37

5.81

243

1.14

1.00

1.30

Urinary bladder

264

1.12

0.99

1.26

104

1.14

0.93

1.39

3

0.75

0.14

2.21

371

1.12

1.01

1.24

Melanoma

114

1.11

0.92

1.33

126

1.08

0.90

1.28

4

1.43

0.37

3.70

244

1.10

0.96

1.24

Skin, squamous cell

209

0.96

0.83

1.10

69

1.04

0.81

1.32

3

0.91

0.17

2.68

281

0.98

0.87

1.10

Nervous system

127

1.08

0.90

1.29

95

1.03

0.83

1.26

1

0.52

0.00

3.01

223

1.05

0.92

1.20

Thyroid gland

42

1.24

0.90

1.68

24

1.02

0.65

1.52

0

   

66

1.15

0.89

1.46

Endocrine glands

76

1.06

0.83

1.32

54

1.10

0.83

1.44

1

1.36

0.00

7.80

131

1.08

0.90

1.28

Connective tissue

29

0.97

0.65

1.39

31

1.91

1.30

2.71

1

11.33

0.00

64.92

61

1.32

1.01

1.69

Non-Hodgkin lymphoma

185

1.00

0.86

1.16

104

1.05

0.86

1.28

2

0.54

0.05

1.98

291

1.01

0.90

1.14

Myeloma

85

1.10

0.88

1.36

25

0.90

0.58

1.33

1

1.62

0.00

9.27

111

1.05

0.86

1.27

Leukemia

95

1.08

0.87

1.32

44

1.04

0.76

1.40

0

   

139

1.06

0.89

1.26

CUP

189

1.07

0.93

1.24

85

1.40

1.12

1.73

0

   

274

1.15

1.02

1.30

All

3188

0.99

0.96

1.03

1133

1.09

1.02

1.15

172

1.24

1.06

1.43

5506

1.05

1.02

1.08

  1. O = observed number of cases in offspring. Bolding shows that the 95% confidence limits (95%CI) do not include 1.00.
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