Figure 1 | Scientific Reports

Figure 1

From: RETRACTED ARTICLE: Overexpression of miR-499-5p inhibits non-small cell lung cancer proliferation and metastasis by targeting VAV3

Figure 1

miR-499-5p is correlated with poor prognosis of NSCLC patients and inhibits cells growth in vitro and in vivo.

(A) Overall survival of NSCLC patients with low and high miR-499-5p expression. (B) Overexpression or inhibition of miR-499-5p significantly inhibited or stimulated NSCLC cells growth. (C) Overexpression or depletion of miR-499-5p inhibited or stimulated colony formation in A549 and H23 cells. (D) Expression of miR-499-5p was increased or decreased in cells stably expressing miR-499-5p or miR-499-5p-antisense compared to vector control. (E) Overexpression or inhibition of miR-499-5p inhibited tumor growth in A549 xenograft model or stimulated tumor growth in H23 xenograft model, respectively. Error bars represent the mean ± s.d. of three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001.

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