Figure 4 | Scientific Reports

Figure 4

From: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

Figure 4

(a): Schematic of Brugia malayi (Bm) SCID mouse PD model with oral dosing regimens (MK: mg/Kg, ip: intraperitoneal route). (b): Effect on Wolbachia depletion following indicated minocycline (MIN). Data plotted is Wolbachia surface protein (wsp) single gene copy number per adult female worm, horizontal bars are median levels. Median vehicle control level is indicated by dashed line. Data is from 10–15 adult female worms pooled from between 5–10 mice per drug treatment. Significant differences between 7 day MIN dose escalation groups and vehicle were compared by Kruskal-Wallis, two-tailed 1-way ANOVA, alpha = 0.05, P < 0.0001 with Dunn’s multiple tests post-hoc comparing all groups indicated *P < 0.05, **P < 0.01 and ***P < 0.001. Significant differences between MIN 25MKbid for 14 or 28d vs corresponding length of vehicle were compared by Mann-Whitney tests, two-tailed, alpha = 0.05, P < 0.0001 indicated***.

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