Table 1 In vitro anti-Wolbachia activities of doxycycline and minocycline in infected A. albopictus cells C6/36 and male Brugia malayi worms.

From: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

 

Doxycycline

Minocycline

In vitro depletion (insect Wolbachia) EC50, (range, n)

15.3 nM (1–147, 396)

11.8 nM (8–34, 6)

In vitro depletion (male B. malayi) @5 μM Median% depletion cf vehicle, (range, n)

65% (14–80%, 10)

66.7% (43–71%, 10)

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