Table 2 Pharmacokinetic parameters for doxycycline and minocycline at steady state (day 7).

From: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

 

Doxycycline

Minocycline

CL/F (L/hr/Kg)

1.2 (0.4)

3.2 (0.3)

V/F (L/Kg)

6.9 (3.9)

13.2 (4.5)

Half-life

4.4 (3.7)

3.0 (2.3)

AUC (mg.hr/L)0–24hr after dose

22.8

8.4

  1. Standard deviations are show in parentheses.
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