Table 3 Parasitological output from comparative in vivo efficacy of clinically bioequivalent doxycycline and minocycline regimens against adult stage Brugia malayi Wolbachia.
Treatment | none | Vehicle (Water) | Doxycycline | Minocycline | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose | – | – | 25MKqd | 25MKqd | 25MKqd | 25MKqd | 25MKbid | 25MKqd | 25MKqd | 25MKqd + 14d | 25MKqd | 25MKqd + 28d | 25MKbid + 28d |
duration | – | +28/42d | +7d | +14d | +21d | +28d | +28d | +42d | +7d | +21d | |||
SCID n | 7 | 22 | 5 | 4 | 4 | 5 | 5 | 9 | 5 | 5 | 5 | 13 | 5 |
AdultB. malayi | |||||||||||||
min | 1 | 0 | 14 | 7 | 11 | 6 | 1 | 1 | 0 | 1 | 8 | 0 | 0 |
Median^ | 3 | 6 | 21** | 9 | 15 | 9 | 6 | 6 | 19 | 10 | 12 | 6 | 6 |
max | 5 | 19 | 22 | 11 | 19 | 13 | 10 | 21 | 23 | 21 | 20 | 15 | 10 |
total | 22 | 122 | 96 | 36 | 60 | 49 | 28 | 69 | 76 | 55 | 70 | 81 | 49 |
FemaleB. malayi(% total) | |||||||||||||
min | 20.0 | 0 | 35.7 | 20.0 | 43.8 | 44.4 | 45 | 36.4 | 0 | 1 | 8 | 0 | 0 |
Median| | 70.8 | 59.2 | 52.9 | 59.8 | 46.4 | 50.0 | 83 | 61.8 | 50 | 60.0 | 54.6 | 66.7 | 70.7 |
max | 100 | 100 | 63.6 | 72.7 | 57.1 | 63.0 | 100 | 100 | 62 | 100 | 63.2 | 100 | 100 |
Female B. malayi n | 13 | 68 | 51 | 19 | 29 | 25 | 17 | 40 | 38 | 30 | 38 | 53 | 32 |
Wolbachia sample n | 13 | 40 | 10 | 10 | 10 | 10 | 10 | 21 | 10 | 10 | 10 | 35 | 21 |
