Table 4 PKPD modelling parameters for doxycycline and minocycline.

From: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

 

Effect site EC50 (nM)

K12/K21

Ratio of AUCPD curve (0→28d)

Doxycycline

15.32

4.36 × 10−7/8.06 × 10−4

1

Minocycline

11.75

1.08 × 10−5/1.49 × 10−3

1.7

  1. Area under the PD curve for a 28 day 25 mg/Kg bid dosing regimen is also shown.
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