Figure 6: Overview of metabolic flux distributions during growth (mock infection) and CAV2 infection.
From: Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production
(A) Schematic representation of metabolic flux distributions in selected reactions. Inside each pair of growth/infected panels, arrow thickness represents the relative net (full) and exchange (dashed) fluxes between conditions. Absolute values are shown in units of nmol/106 cells/h. Percentage values represent the proportion of pentose-phosphates that are cycle back to glycolysis. (B) Estimated fluxes and associated 95% confidence lower and upper bounds of the shown reactions. ACL, ATP-citrate lyase; AKGDH, alphaketoglutarate dehydrogenase; AT, alanine aminotransferase; IDH, isocitrate dehydrogenase (lumps aconitase activity); IDHe, IDH exchange flux; GDH, glutamate dehydrogenase; LDH, lactate dehydrogenase; MDH, malate dehydrogenase; ME, malic enzyme; PC, pyruvate carboxylase; PDH, pyruvate dehydrogenase; PK, pyruvate kinase; PPPox, pentose-phosphate pathway, oxidative branch; PT, pyruvate transport flux; PTe, PT exchange flux.
