Figure 3 | Scientific Reports

Figure 3

From: Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway

Figure 3

Effects of knockdown of ACAT-1 and VCAM-1 on foam formation and monocyte recruitment response to salusin-β in VSMCs.

VSMCs were transfected with ACAT-1 or VCAM-1 siRNA or scrambled siRNA (100 nM) for 24 h and then treated with or without salusin-β (30 nM) for 48 h. (A) effects of ACAT-1 siRNA on salusin-β-induced foam formation. (B) effects of VCAM-1 siRNA on monocyte recruitment response to salusin-β. (C) effects of ACAT-1 siRNA on the intracellular cholesterol content in response to salusin-β. (D) effects of VCAM-1 siRNA on salusin-β-induced monocyte adhesion. Values are mean ± S.E.M. *P < 0.05 and **P < 0.01 vs. PBS. †P < 0.05 and ††P < 0.01 vs. Scr siRNA. ‡P < 0.05 and ‡‡P < 0.01 vs. Veh (vehicle). n = 6 for each group in (C) n = 4 for other groups.

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