Table 3 Comparison of ROC curves and reclassification analysis for modified bleeding scores with TTR.

From: Major Bleeding in Patients with Non-Valvular Atrial Fibrillation: Impact of Time in Therapeutic Range on Contemporary Bleeding Risk Scores

 

AUC

p*

NRI

p

IDI

p

 

vs ORBIT

ORBIT + TTR< 65%

 0.609

0.106

0.2508

0.0054

0.0023

0.0092

 

vs ATRIA

ATRIA + TTR< 65%

 0.611

0.052

0.250

0.0054

0.0020

0.0014

 

vs HEMORR2HAGES

HEMORR2HAGES + TTR< 65%

 0.578

0.028

0.263

0.0034

0.0015

0.0016

  1. AUC = area under the curve; IDI = integrated discriminatory improvement; NRI = net reclassification improvement. *z test for AUC comparison.
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